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KMID : 0605719980040010001
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Journal of the Korean Society of Biological Therapies in Psychiatry
1998 Volume.4 No. 1 p.1 ~ p.11
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Efficacy of Clozapine in Treatment-resistant Schizophrenic patients
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1곽경필/1Kyung Piil Kwak
1강병조/2/3정철호/4추동호/4김성욱/5김주찬/1Byung Jo kang/23Chul Ho Jung/4Dong Ho Chu/4Sung Wook Kim/5Joo Chan Kim
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Abstract
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The purpose of this study was to investigate the efficacy of clozapine in the
treatment of treatment-resistant schizophrenic patients.
This multicenter open study included 77 patients drawn from 3 hospitals in Taegu.
After a wash-out period of 7 days, subjects were treated with clozapine according to a
standardized titration and dosage schedule for 12 weeks and evaluated at 4 points ; at
baseline, and 4, 8, and 12 weeks of treatment. Patients who tolerated and responded to
treatment were maintained on a regimen(100-600mg/day) of clozapine. The psychiatric
severity and functioning status of the patients were assessed by PANSS, CGI, and GAP
scale.
The mean daily dosage of clozapine was 333.57±127.0mg. All rating scores on the end
point(N=70) demonstrated a significant improvement compared with baseline. Significant
improvements in both PANSS positive and negative subscale scores was as early as
week 4 through week 12.
The tolerability of clozapine was generally found to be good. Hypersalivation(90.0%),
sedation(66.7%), and constipation(61%) were the most common adverse effects.
Our results suggest that clozapine is an effective antipsychotic drug fro the
treatment-resistant schizophrenics, who are non-responsive to classical antipsychotic
drugs.
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